![]() Niacin-bound chromium(III) has been demonstrated to be more bioavailable and efficacious and no toxicity has been reported. Recently, chromium picolinate has been shown to be mutagenic and picolinic acid moiety appears to be responsible as studies show that picolinic acid alone is clastogenic. Studies have implicated the toxicity of chromium picolinate in renal impairment, skin blisters and pustules, anemia, hemolysis, tissue edema, liver dysfunction neuronal cell injury, impaired cognitive, perceptual and motor activity enhanced production of hydroxyl radicals, chromosomal aberration, depletion of antioxidant enzymes, and DNA damage. Comparative studies of chromium(III) picolinate and niacin-bound chromium(III), two popular dietary supplements, reveal that chromium(III) picolinate produces significantly more oxidative stress and DNA damage. Chromium(VI) induced more pronounced oxidative damage in multiple target organs in p53 deficient mice. To evaluate the role of p53 gene, the dose-dependent effects of chromium(VI) were assessed in female C57BL/6Ntac and p53-deficient C57BL/6TSG p53 mice on enhanced production of ROS, lipid peroxidation and DNA fragmentation in hepatic and brain tissues. Chromium(VI) demonstrated significantly higher toxicity as compared with chromium(III). In this paper, comparative concentration- and time-dependent effects of chromium(VI) and chromium(III) were demonstrated on increased production of reactive oxygen species (ROS) and lipid peroxidation, enhanced excretion of urinary lipid metabolites, DNA fragmentation and apoptotic cell death in both in vitro and in vivo models. Conversely, chromium(III) is essential for proper insulin function and is required for normal protein, fat and carbohydrate metabolism, and is acknowledged as a dietary supplement. The mechanistic cytotoxicity of chromium(VI) is not completely understood, however, a large number of studies demonstrated that chromium(VI) induces oxidative stress, DNA damage, apoptotic cell death and altered gene expression. Chromium(VI) is commonly used in industrial chrome plating, welding, painting, metal finishes, steel manufacturing, alloy, cast iron and wood treatment, and is a proven toxin, mutagen and carcinogen. Your body will thank you for it.Chromium exists mostly in two valence states in nature: hexavalent chromium and trivalent chromium. Be sure to have chromium by your side when those sweet cravings hit. This particular composition is considered to be one of the safest and most efficient delivery forms of chromium. ![]() It may also help to reduce the risk of coronary heart disease and metabolic conditions.ĬanPrev’s Chromium Nicotinate Glycinate 200 contains a blend of chromium, glycine and niacin (vitamin B3) and is a superior formulation when it comes to absorption and gentleness. When it comes to blood sugar regulation and lipid, carbohydrate, protein and corticosteroid metabolism, chromium is key. Niacin, also known as vitamin B3, helps to increase the absorption of chromium and at the same time allows for the release of chromium as a biologically active agent. Also, the intestinal absorption rate of chromium is very low. ![]() Both of these factors are a result of industrialized farming and food manufacturing methods. ![]() So how much is too much?Įven a well-balanced diet can contain sub-optimal levels of chromium because of mineral-poor soil and the rigors of food refining. Ironically, chromium is what your body needs to metabolize glucose and regulate blood sugar levels in the body. Do you have a sweet tooth? If you consider sugar a sixth food group, you may be depleting your chromium stores by overindulging. ![]()
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